Missy Franklin has missed out on another event that was part of her Olympic program four years ago.
Franklin was only the 11th-fastest qualifier in the semifinals of the 100-meter freestyle at the U.S. swimming trials Thursday night, missing a spot in Friday's final. Abbey Weitzeil was the top qualifier at 53.57 seconds, and Katie Ledecky also advanced as the seventh seed at 54.04.
The top eight will swim in the final.
Also advancing were Simone Manuel (53.64), Amanda Weir (53.72), Dana Vollmer (53.74), Lia Neal (53.87), Kelsi Worrell (54.00) and Allison Schmitt (54.07).
Franklin could only produce a time of 54.24, while Natalie Coughlin's Olympic hopes likely ended altogether.
The 12-time Olympic medalist struggled to a 14th-place showing in 54.87.
In 2012, Franklin finished fifth at the Olympics in the 100 free, one of seven events on her grueling program. So far, she's qualified in only one individual event, the 200 freestyle.