Edmonton broke the deadlock three minutes into the second as Draisaitl put on a clinic, faking out Mikko Rantanen before beating Varlamov up high with a backhander for his 18th of the season.
A few minutes later, Varlamov was able to stop McDavid on a clear breakaway and later in the period did the same against Edmonton forward Anton Slepyshev.
Edmonton made it 2-0 with 5 1/2 minutes to play in the second when Mark Letestu hooked a shot in front to help Kassian score his seventh.
Colorado got a goal back with 19 seconds remaining in the period when Girard's point shot hit the post and caromed in.
The Avalanche tied the game 50 seconds into the third when a pass deflected off an Oilers defender to Wilson, who scored his sixth of the season.
Edmonton won the season series 2-1, including a 4-2 victory on Sunday when McDavid had a hat trick. ... Out of the lineup for the Oilers were Ryan Nugent-Hopkins (upper body), Andrej Sekera (head), Patrick Maroon (lower body) and Drake Caggiula (illness). ... Absent for the Avalanche were Vladislav Kamenev(arm), Mark Barberio (lower body), Jonathan Bernier (concussion), Erik Johnson (upper body), Sven Andrighetto (leg) and Anton Lindholm (upper body).
Avalanche: Conclude a three-game road trip Saturday in Calgary.