Jokic also had 12 rebounds, five assists, two steals and two blocks. He is the ninth player in NBA history to have those totals to go with 41 points and at least four 3-pointers.
He left the game early in the fourth still shy of his career high of 40 points set Feb. 10 against New York but returned late in the fourth. He scored two quick buckets and then fouled out, but only after his teammates gently encouraged him to shoot.
"If you pass the ball, the ball will find you at some point," Jokic said. "You don't need to be selfish. When you have the open shot, just take it."
The Nets starters couldn't match Jokic's output. The five combined for 40 points and watched from the bench as Jokic outscored them with his four points late in the game.
"He went out there and put on a show," Barton said. "When a guy's rolling like that, you want to see him keep it going and get as many points as possible."
"I don't think we had the requisite juice. The execution wasn't good," Brooklyn coach Kenny Atkinson said. "It was like we were walking in mud in everything we did."
Jokic scored in bunches, and each time he helped Denver extend leads. He had 11 points in the second when the Nuggets led by 13, and he scored 14 more in the third to help push the lead to 86-61.
Brooklyn went on a 13-4 run in the final 2:59 to make it a closer game.
The Nets committed a season-high 25 turnovers, which led to 27 points for Denver. They had just 16 turnovers in the win over Phoenix on Monday night.
"Turnovers were such a big issue tonight and then we came out a little lackadaisical and no energy," DeMarre Carroll said. "I thought our defense was pretty good but we kept turning it over and they got easy offense."
Nuggets guard Gary Harris was the most disruptive. He had a career-high six steals against Brooklyn.
"That's what Gary does," Nuggets coach Michael Malone said. "He is a guy that can be physical and get to you and blow up the offense, and he did that tonight."