Manning had a pair of TD throws to tight end Julius Thomas in the first half of Denver's season opener.
Manning hit Andre Caldwell and then Wes Welker twice for touchdowns in the third quarter, giving the Broncos a 35-17 lead.
Welker, who earlier muffed a punt, caught Manning's pass in the left flat and circled around defender Corey Graham for a 5-yard score that tied Favre's NFL mark. He was then wide open for a 2-yard TD catch.
Manning said Broncos fans helped, too.
"The crowd was awesome. They were into it. They stayed with us...The crowd was really tough on their offense all night"