Trent Cole is one of the Eagles main pass rushers. Cole has amassed 71 career sacks. Even though Cole hasn't recorded a sack on the season, it's important that Broncos tackle Chris Clark keeps the dangerous pass rusher away from Peyton Manning.
Peyton Manning will face an Eagles secondary that is ranked 29th, giving up 323 yards per game. The pressure will fall on Eagles rookie safety Earl Wolff who is expected to start in place of injured veteran Patrick Chung.
With the unknown status of Champ Bailey, the assignment of covering Jackson will fall on Rodgers-Cromartie. Look for the Eagles to try to get the ball in Jackson's hands early and often in the no-huddle offense.
Since being named the Eagles starting quarterback in 2010, Vick has a 9-13 record when he has thrown an interception. The Broncos will try to keep the dual threat quarterback in the pocket and force him to beat them with his arm.
The game headline may be the aerial attacks from the Eagles and Broncos, but the spotlight will be in the trenches. McCoy leads the league in rushing with 395 and the Broncos defense has only given up 43 yards per game.