(Sports Network) - Greg Maddux will try again for career win No. 350 when he leads the San Diego Padres tonight in the second test of a three-game series versus the Colorado Rockies at Petco Park.

Maddux has lost two straight starts and is 0-3 with a 5.54 ERA in his previous four trips to the hill. In his last attempt at win No. 350 on Sunday at Florida, Maddux was reached for five runs -- four earned -- and 11 hits in 5 2/3 innings of a 10-3 setback at Dolphin Stadium.

The veteran right-hander and future Hall of Famer is 2-3 with a 4.09 ERA in seven starts this season. Maddux is 14-8 with a 4.14 earned run average in 27 career appearances against Colorado.

San Diego continued its struggle with Friday's 4-2 loss to the Rockies in the opener of this set. It has dropped five straight, seven of eight and 18 of the last 22 games to remain last in the NL West division. The Padres will try to avoid losing six straight for the first time since an eight-game skid from July 17-26 of the 2005 season.

Brian Giles hit an RBI double and Kevin Kouzmanoff had a solo home run in defeat. Padres ace Jake Peavy suffered the loss after he was touched for three runs on seven hits in six frames.

Garrett Atkins went 3-for-4 with an RBI for Colorado. Brad Hawpe ended 1-for-4 with a pair of RBI and Matt Holliday added a solo homer and scored twice, as the Rockies posted their third straight win and opened a six-game trip on a good note.

Aaron Cook got the win after he pitched seven innings and only yielded one run on three hits. Brian Fuentes earned his fourth save of the year despite giving up a solo homer to Kouzmanoff in the ninth.

Ubaldo Jimenez gets the nod for the Rockies on Saturday, and he is 1-2 with a 5.82 ERA in seven starts this season. He has registered four straight no decisions and is 0-1 over the past five trips to the hill.

Jimenez last pitched on Monday versus St. Louis and did not factor in the outcome of a 6-5 setback. He yielded four runs -- three earned -- and seven hits in five innings of work.

Jimenez lost to the Padres on April 15 this season, allowing six runs -- two earned -- in 4 2/3 frames of a 6-0 loss at Petco Park. The righty is 1-1 with a 2.55 ERA in three career starts against San Diego.

Colorado won two of three games against the Padres from April 15-17 at Petco Park. The Rockies have won eight of the nine most recent matchups in the series.