DENVER -- This Nov. 4, Colorado voters will see something they've never seen in their lifetimes: a ballot with 18 state issues and all the various candidates and local questions.

After proposed Amendment 82 was rejected Wednesday by the Secretary of State, the final number was set at 18.

"The momentum is strong and we plan to keep it until November," said Kelley Harp, spokesman for A Better Colorado, behind Amendment 47, the "right to work" issue. Some will call the measure "anti-union" or "pro-business."

Protect Colorado's Future will oppose Amendment 47 and back several other measures many would call "pro-union."

"When you have these out-of-state, or narrow corporate interests trying to divide Coloradans, it's bad for all Colorado," said Jess Knox, wearing a pin that says, "No on 47, 49 and 54."

While both campaigns will spend plenty on advertising to defeat each other, they agree this ballot will be unusually long.

"We're trying to uphold the integrity of that process. And we believe that when those rules and regulations are upheld and really drove down into, a lot of these questions wouldn't have qualified for the ballot," Knox said.

"It is a long ballot. Some people worry about voter fatigue. I don't," Harp said. "It's not always a bad thing. Most people view it as a good thing. It's another way to keep elected officials accountable."

"What we're doing now is not good government and it's not good democracy," said Steve Burkholder, chairman for "O" Yes For Colorado.

Referendum "O" would increase the number of signatures needed to get a constitutional amendment on the ballot and decrease the number needed to get a state law put before the voters. A bi-partisan group that supports the idea, including Democratic State Sen. Ken Gordon and Republican Rep. Al White.

They believe getting amendments on the ballot has become too easy and often leads to wildly conflicting amendments that hamstring lawmakers.

"I mean, it just creates conflicting mandates. So our legislature says, 'Well, you've got to spend this or you've got to cut here.' And, that really is not good for our state," Burkholder said.

Major Issues In November

PERSONHOOD: A proposed constitutional amendment would define a person "to include any human being from the moment of fertilization." Supporters and opponents agree the language would set constitutional groundwork for banning abortion.

AFFIRMATIVE ACTION: This amendment would ban preference based on race or gender in state hiring and admission to public universities.

TAXPAYER BILL OF RIGHTS: Colorado's pioneering requirement that excess tax receipts be returned to voters would be tweaked to allow extra funds to go to education.

RIGHT TO WORK: A group of businessmen led by brewery heir John Coors back this amendment allowing workers to opt out of unions in already-organized work sites.

CORPORATE FRAUD: Several labor unions are pushing a measure to make it easier for CEOs to be held criminally responsible for corporate fraud.

FIRING EXPLANATION: Another union-supported measure would require employers to give formal explanations for firing people.

HEALTH CARE: The amendment requiring businesses with more than 20 workers to provide health insurance also has union backing.

SALES TAX: Colorado will consider raising its sales tax one-tenth of 1 percent in each of the next two years, with the estimated $186 million raised each year going to services for the disabled.

BALLOT MEASURES: Finally, Colorado will be asked whether the citizen initiative system itself should be tweaked to require more signatures before questions can get on ballots.