Denver, CO -- (Sports Network) - Ben Roethlisberger threw for 233 yards and a trio of scores and Pittsburgh's defense came up with three interceptions of Kyle Orton in a 28-10 triumph over the Denver Broncos. Tyrone Carter, starting in place of Ryan Clark, had a pair of interceptions, returning one 48 yards for a touchdown. Troy Polamalu's pick-off set up Roethlisberger's 25-yard scoring toss to Mike Wallace in the fourth quarter. Roethlisberger connected on 21-of-29 passes and was picked off once as the Steelers (6-2) won their fifth straight game. Rashard Mendenhall rushed 22 times for 155 yards, while Hines Ward had a pair of TD catches as Pittsburgh controlled the clock in the second half. Santonio Holmes caught six balls for 93 yards for Pittsburgh, which next hosts Cincinnati in a battle for first place in the AFC North. Clark was inactive due to a blood disorder which makes it dangerous for him to play in high altitudes. He was forced to miss the remainder of the 2007 season after suffering a ruptured spleen following the Steelers' last game at Denver, in December, 2007. He also had to undergo surgery to remove his gall bladder and lost 30 pounds before making a full recovery. After Carter's second interception, with 15 seconds remaining, Clark jumped up and celebrated with his teammates. Orton connected on 23-of-38 passes for 221 yards for the Broncos (6-2), who were coming off a 30-7 blowout loss at Baltimore. Brandon Marshall had 11 receptions for 112 yards, but Denver's running game was nonexistent as the Broncos combined for 27 yards on the ground.