At least 45 dead, 141 wounded after car bomb explodes in Karachi, Pakistan

KARACHI, Pakistan - Police say a car bomb killed at least 45 people and wounded 141 people in the city of Karachi in Pakistan.

Karachi, Pakistan's economic hub, has been the site of political, sectarian and ethnic violence for years and is dominated by Shiite Muslims. No one has taken responsibility for the bombing, but Shiites Muslims have been increasingly targeted by Sunni militant groups.

The bomb exploded outside a Shiite mosque as people were leaving evening prayers.

A top government official, Taha Farooqi, says at least 37 people are confirmed dead and 141 more were wounded.

Initial reports suggested the bomb was rigged to a motorcycle, but a top police official Shabbir Sheikh said around 220 pounds of explosives was planted in a car.