Colorado is on pace to break a rabies case record as the disease spreads in skunks from the eastern plains to the Front Range. "This is a good time to remind people to keep their pets rabies vaccinations up to date and take a few simple precautions to avoid pets coming in contact with wildlife, said Elisabeth Lawaczeck, state health veterinarian at the Colorado Department of Public Health and Environment. "Having pets vaccinated is the simplest and most effective way to protect pets and family members from this deadly disease. I encourage pet owners to contact their veterinarian and get their pets up to date on vaccinations," she said. There have been 99 confirmed rabies cases so far this year, the health agency said. The cases include 34 skunks, 54 bats, seven foxes, one domestic cat, one horse, one mule deer and one muskrat. In 2009, 103 animals tested positive for rabies in Colorado, which broke the states previous annual record -- 70 cases in 2006, all of which were bats. The rabies virus affects the nervous system of humans and other mammals and can be fatal, officials state. The virus is transmitted in the saliva of infected animals. People and animals get rabies from the bite of a rabid animal or direct contact with saliva from such an animal. The state collaborates on a rabies tracking project with local health departments, animal control agencies, state agriculture and wildlife agencies and Colorado State University. "Skunks are highly efficient at transmitting rabies to other animals, much more so than bats," Lawaczeck said. State health and wildlife experts can't explain the rapid spread of skunk rabies in Colorado. "Although skunks typically travel only within a half-mile radius, officials suspect that people might be trapping and relocating skunks, which is illegal according to Division of Wildlife regulations," a state health agency news release said. Signs of rabies in animals include abnormal behavior such as nocturnal animals being active in the day, wild animals approaching humans or other animals, difficulty walking or moving, and unusual animal sounds such as excessive bellowing in cows or hissing and chirping in bats. Some animals with rabies will be very aggressive, known as furious rabies. Yet others creatures may appear almost catatonic, called dumb rabies, the release said. Skunks and other wildlife should not be handled or fed. If a wild animal allows a person to approach and handle it, the animal probably is ill or injured and will bite in self-defense. State officials warned the public to immediately report any suspected rabid wild animal, such as a skunk, bat, fox or raccoon, to animal control authorities. If the animal is sick or injured, contact a local Division of Wildlife office. Hit are precautions to avoid possible exposure to rabies: Do not feed wild animals. This just brings them closer to your family and reduces their natural fear of humans. If you encounter a skunk, raccoon or other carnivore during daytime hours, leave it alone. If the animal appears sick or aggressive, call your local animal control agency or the Division of Wildlife. Teach children to stay away from wild or dead animals. Do not allow pets to roam freely, as this increases the chance they may be exposed without your knowledge. Keep your pets rabies vaccination current, and maintain vaccination records. If you cant afford to vaccinate your pet for rabies through your local veterinarian, check with local animal shelters or humane societies for reduced vaccination fees. Discuss rabies vaccination of your livestock with your veterinarian. Vaccination should be considered for horses and other equines, breeding livestock, dairy cattle or other high-value livestock, especially in areas of the state where skunks have been diagnosed with rabies. Contact your veterinarian if your dog or cat is bitten or scratched by a wild animal, such as a skunk, bat, fox or raccoon, or comes home smelling like a skunk. If a family member or pet has been bitten or scratched by a wild mammal, contact your local public health agency and consult with a physician without delay.If you have questions about rabies or about whom to call in your area to respond to a wild or suspect animal, please call COHELP at 1-877-462-2911 for more information.