Racers with the USA Pro Cycling Challenge will ride from Breckenridge to Colorado Springs on Friday.
The 117.9 mile course includes a climb up the 11,500-foot Hoosier Pass.
After the single summit of the day and a fast descent into Fairplay, the high mountains are left behind, race officials said.
Riders will descend into Woodland Park where they are expected to hit their fastest speeds of the week at the downhill Sprint Line.
After that, they'll continue downhill on Highway 24 to Colorado Springs. A technical uphill climb through Garden of the Gods Park will let the cyclists revisit the roads of last years prologue before finishing with high-speed circuits through downtown Colorado Springs.
Stage 5 is expected to begin at 10:50 a.m. and end around 3:50 p.m.
Twenty riders have dropped out since the race began, including seven riders who didn't finish the fourth stage from Aspen to Beaver Creek on Thursday.
Germany's Jens Voigt won that stage while American Tejay Van Garderen regained his tiebreaker edge for the overall lead.
For Stage 6, riders return to Golden, which hosted one of the races largest crowds during the 2011 race. Day 6's ride takes the cyclists from Golden to Boulder, then on a circle tour of the mountains starting with a 15 mile climb up Boulder Canyon to the town of Nederland, a ride along Peak to Peak Highway to a sprint line in Lyons. Then riders will climb up Left Hand Canyon and Lee Hill Road, back to Boulder. The race will end with a final 3.5 mile climb to the historic Sunrise Amphitheater on Flagstaff Mountain.
The final day is a flat and fast time trial course in downtown Denver.
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