Highway 85 was closed north of Sedalia, Colo., following a fatal accident involving three vehicles late Friday afternoon, but reopened three hours later.
The Colorado State Patrol said that one person was killed in the accident, which occurred at 3 p.m.
The two other drivers were seriously injured in the crash, 7NEWS reported. Each vehicle contained one person.
Traffic was detoured onto a side road for three hours while the investigation into the accident continued.
According to the State Patrol, the chain-reaction accident was caused by a pick-up driving in the wrong lane of traffic, hitting a commercial truck head on. The impact knocked the truck into the opposite lane of traffic, where it collided with a minivan, the State Patrol said.
The driver of the pick-up was killed in the impact, 7NEWS reported.