Here are the five matchups to watch for between the San Diego Chargers and the Denver Broncos.
Phillip Rivers is 5-2 when facing the Broncos on the road. He will try to get his sixth win against the Broncos 28th ranked pass defense.
Keenan Allen leads all rookie receivers with 61 catches and 902 receiving yards. In the first game, Dominique-Rodgers Cromartie held Allen to four catches for 41 yards.
With Wes Welker out with a concussion injury, the Broncos will insert tight end Jacob Tamme into the lineup. Tamme caught 52 passes last season.
Knowshon Moreno is 80 yards shy of his first 1,000 yard rushing season. Moreno will try to become the first Broncos to hit the 1,000 yard mark since Willis McGahee in 2011.
Danny Trevathan leads the Broncos in tackles and is tied for the lead in interceptions. He will cover Chargers running back Danny Woodhead who is second on the team with 65 receptions.