Why Throat Cancer May Be On Rise
Oropharynx Cancer Cases May Be Due To HPV
POSTED: 1:47 pm MDT April 13, 2011
UPDATED: 1:54 pm MDT April 13, 2011
HOUSTON -- (Ivanhoe Newswire) -- Over the past 30 years in America, the smoking rate has plunged considerably. As a result, the throat cancer rate has dropped across all types, except one: oropharynx cancer. This type is suddenly -- and dangerously -- on the rise.Paul Wyett has been through a rough couple months.“I was fine. Healthy. Then, all of a sudden, I was in a surgery room for the first time in my life,” Wyett said.
Last August, he was diagnosed with oropharynx cancer. It’s a type of throat cancer experts say may double in 10 years.“You can actually grow quite a large tumor, even the size of a golf ball or bigger, in the back of your tongue or in your tonsil and not know it,” said Dr. Ron Karni, from UT Health/Memorial Hermann in Houston.Now, it’s popping up in patients without warning.“We see them in people who don’t have any risk factors in regards to smoking or alcohol,” Dr. Karni said.Experts are now blaming part of the cancer’s rise on the human papillomavirus (HPV).“We’re certainly seeing the evidence of some of the changes that that virus causes to the cell in patients who have HPV-related cancers,” Dr. Karni said.As a result, experts hope the Gardasil vaccine, which protects younger people against HPV may prevent oropharynx cancer, too. In 2009, about 70 percent of oropharynx cancers were HPV-positive. In 2003, it was just 35 percent.“We’ll probably have to wait a whole generation before we can look back and say that we’ve seen a marked reduction in head and neck tumors because of the vaccines we’re giving today,” Karni said.Wyett had robotic surgery, chemo and radiation for his tumor.“This was just a little speed bump in the road that you just deal with, and you go on,” Wyett said.One of the HPV types that Gardasil protects against is found in up to 90 percent of HPV-positive oropharynx cancers. The HPV vaccine is currently approved for men and women between ages 9 through 26 years old.
BACKGROUND: The oropharynx is the middle part of the throat, and includes the base of the tongue, tonsils, the back of the mouth, and the walls of the throat. When cancers form in these areas, they are usually squamous cell carcinomas. When left untreated, oropharynx cancer is usually fatal.Symptoms of oropharynx, or oropharyngeal, cancer can be difficult to detect, but they include a chronic sore throat, unexplained weight loss, voice changes, difficulty swallowing, ear pain, and lumps in the neck, mouth, or the back of the throat. However, lumps in the neck, mouth, or back of the throat usually mean that the cancer has already started to spread to the lymph nodes. (SOURCE: www.clevelandclinic.org)
RISK FACTORS: The risk factors for oropharyngeal cancer include excessive drinking and tobacco use. Doctors have also found links between oropharyngeal cancer and the human papilloma virus, or HPV, which is usually associated with cervical cancer. Increasing numbers of oropharynx cancer patients also test positive for HPV. (SOURCE: www.mayoclinic.org)
TREATMENT: Treatment for oropharyngeal cancer usually includes radiation, chemotheraphy, or surgery. Due to the nature of the symptoms, oropharynx cancer is often detected late, and therefore it's important to get started on treatment as soon as possible. In the past, surgery for oropharynx cancer was extremely invasive and had significant negative impact on a patient's ability to speak and swallow: the procedure involved splitting the jawbone in order to gain access to the tumors and lymph nodes.However, newer treatments are far less invasive and have shorter recovery times. They include laser therapy, which uses beams of light to shrink tumors, and robot assisted surgery, in which the surgeon remotely operates hand controls that hold surgical instruments. This procedure allows the surgeon to operate on areas that are usually harder to reach. Though the newer treatments for oropharyngeal cancer are vast improvements over older procedures, the link between the HPV virus and oropharynx cancer suggests that the cancer might actually be preventable-- if the relationship between HPV and oropharyngeal cancer is causal, the HPV vaccine, Guardasil, would be an effective tool in curbing the rise of oropharynx cancer.
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